Day 1 :
- Track 1: Infection Prevention, Control and Cure
Track 2: Infection Control Procedures
Track 3: Immunizations
Track 4: Epidemiology and Infection Control
Track 5: Microbial Pathogenesis and Virulence
Track 6: Hospital Infections and Epidemiology
Track 7: Infection Control in Critical Care
Track 8: Infection Control in Dialysis
Location: Rome, Italy
University of Antwerp
Dr. Tomislav Kostyanev obtained his medical degree in Sofia, Bulgaria in 2007 and a specialty in medical microbiology at the Medical University of Sofia in 2012. He has also a second master degree in public health obtained in the same university. During his residency in microbiology, he worked as teaching assistant, teaching medical microbiology to students in medicine, pharmacy and dentistry. Since 2013, Dr. Kostyanev has been working in the Laboratory of Medical Microbiology at the University of Antwerp, Belgium as a full-time researcher in the COMBACTE project, an EU funded initiative which aims to develop clinical and laboratory network for clinical trials of anti-invectives in Europe. He is involved in several projects including studies on development of new antibiotics against carbapenem-resistant Gram-negative pathogens. Dr. Kostyanev had several specializations and short-term research stays in France, Spain and the United Kingdom. His professional interests are in the field of antimicrobial resistance and antibiotic policy
Antibiotic resistance (ABR) has now been recognized as a global public health threat, causing at least 700,000 death cases every year. Therefore, it is essential that new and rapid solutions are found to effectively overcome the consequences of ABR. Many pharmaceutical companies have found difficulties to invest in antibiotic drug discovery and development in the last two decades, mainly because of low economic return of investment. The Innovative Medicines Initiative Joint undertaking (IMI JU) has addressed this issue by investing more than 660 million euro in seven projects clustered in the New Drugs for Bad Bugs programme. These projects encompass all aspects of drug development from basic science and drug discovery, through clinical development to new business models and responsible use of antibiotics.
The main objectives of the COMBACTE consortia are to deliver clinical trials in collaboration with pharmaceutical companies and to build clinical and laboratory networks to optimise scientific evaluation of new antimicrobials within Europe. The COMBACTE consortium now consists of 55 academic and 8 industrial partners and spreads in 42 countries, including more than 800 hospitals. The main objective of LAB-Net, one of the four pillars of COMBACTE, is to establish a European-wide network of laboratories that plays a key role in clinical trials on anti-infectives. By being part of LAB-Net, laboratories can benefit from training programmes and activities to build laboratory capacity and infrastructure.
One of the ultimate goal of COMBACTE is to evolve into a self-sustainable clinical trial infrastructure which will support trials of anti-infectives after the formal close-out of the IMI-funded programme. The vision of such a network would be to efficiently generate rigorous evidence for new or improved diagnosis, prevention and treatment of infections and to better respond to infectious disease threats. This would be facilitated by a European multidisciplinary clinical network and innovative research approaches.
Waleed A. Mazi is a Regional Director for Infection Prevention and Control, Taif – Saudi Arabia, and also worked in Philosophy of Medical Science, Clinical Microbiology in Sweden. He also Became Infection Prevention and Control Director, King Abdul Aziz Specialist Hospital – Taif, Saudi Arabia, and published many International articles on prevention of central line –associated bloodstream infection, WHO- Hand Hygiene implementation program, prevention sharp injuries in healthcare settings and molecular genotyping for epidemiological purposes and also participated in the Poster and oral presentations in many international conferences
Effective infection prevention and control programmes in hospitals are essential to prevent infections whenever possible. Healthcare-associated infections (HAIs) are the most adverse event threatening hospital patient safety worldwide. Many factors contribute to the risk of HAIs. Information resources are freely available from many national and international professional health agencies. We observed reduction of device healthcare associated infections after introduced Society for Healthcare Epidemiology of America (SHEA) /Infectious Diseases Society of America (IDSA) basic practice recommendations in acute care hospital.
To reduce and control of central line-associated bloodstream Infection (CLABSI), catheter associated urinary tract infections (CAUTI) and ventilator associated pneumonia (VAP) in acute care hospital.
A prospective study to reduce HAIs was conducted in tertiary hospital in 2012. Criteria and incidence rate of CLABSI, CAUTI and VAP were defined according to NHSN guidelines. Hand hygiene observation (HHO) was conducted using the WHO “My five moments” for hand hygiene recommendations. Prevention measures were implemented using SHEA/IDSA basic practice guidelines.
We observed significantly reduction of CLABSI, CAUTI and VAP after implementation SHEA/IDSA practice guidelines.
SHEA/IDSA basic practice guidelines are effective infection prevention model. The strategic plan steps were successfully targeted the goals. It is possible to achieve and maintain zero tolerance without any additional coast
Medical Acupuncture and Pain Management Clinic
Huang Wei Ling, born in Taiwan, raised in Brazil since the age of one, graduated in medicine in Brazil, specializing in infectious and parasitic diseases, a General Practitioner and Parenteral and Enteral Medical Nutrition Therapist. Once in charge of the Hospital Infection Control Service of the City of Franca's General Hospital, she was responsible for the control of all prescribed antimicrobial medication, and received an award for the best paper presented at the Brazilian Hospital infection Control Congress in 1998.
She was coordinator of both the Infection Control and the Nutritional Support Committee in Sao Joaquim Hospital in Franca, and also worked at the infectious Sexually Transmitted Disease Reference Center. She is the owner of the Medical Acupuncture and Pain Management Clinic, and since 1997 has been presenting her work worldwide concerning the treatment of various diseases using techniques based on several medical traditions around the world.
Statement of the problem: As we know osteomyelitis is a bone infection which can reach a bone by traveling through the bloodstream or spreading from nearby tissue. It can also begin in the bone itself if an injury exposes it to germs. Once considered an incurable condition, osteomyelitis can sometimes be successfully treated today by surgery to remove parts of the bone that have died and then with strong antibiotics. (Mayo) The purpose of this study was to show why the treatment of osteomyelitis is so difficult and in most cases incurable. However to improve chances of cure, we need to look at the patient in his entirety, and associate other theories that can be found within other traditions, and not only focus on the infected area. The methodology used was the presentation of two case reports, of which the first showed an infection resulting from knee fracture surgery done after a motorcycle accident that had been treated by the use of a large spectrum of antibiotics without any improvement. The second case was another hospital osteomyelitis after an exposed tibia fracture also after a motorcycle accident which had been treated profusely with antibiotics with any improvement. Findings: Both cases were treated successfully taking out all the anti-inflammatory and antibiotic drugs, and then treated by changing diet, balancing the Yin, Yang, Qi, Blood energy and removing heat retention following the theories of Oriental Medicine. In these two cases, the condition that was maintaining the symptoms of infection was exactly the aggressive use of antibiotics. Conclusion: The treatment of osteomyelitis showed in this study, demonstrated to us that we need to see the patient and not only the disease, to treat adequately the symptoms presented by the patient, and both cases were successfully treated without the use of antibiotics
University of Nottingham
Asha Hassan is in the final stages of completing her Doctorate in Immunology at the University of Nottingham. She is an individual with an extreme passion for humanitarian aid, particularly within the promotion of human welfare to eliminate vaccine preventable infectious diseases, in countries with poor public health provisions. Her current Ph.D. research focus is the epidemiology of Neglected Tropical Diseases (NTD’s), particularly Necator americanus, with a focus on the rational design of an innovative and more efficient intervention strategy against vaccine preventable NTD’s.
Outside of research, Asha has worked extensively with a variety of organizations and is due to be presenting her research at the 4th international conference of Parasitology (Prague, Czech Republic) and the 11th annual NTD conference (Nairobi, Kenya)
Despite the profound health implications of Necator americanus (N. americanus) infection in humans, many aspects of its interaction with the host immune system are poorly understood. In this context, we studied the direct effects of N. americanus larvae (L3) on the phenotype and function of human dendritic cells (DCs). For the first time our data show that L3 N. americanus larvae exsheathed in the presence of DCs and sequestered the immune cells onto the discarded cuticle sheath. Intriguingly, bystander DCs had negligible interaction with the emerging larvae, alluding to a disparity between the surface chemistry of the larval sheath and its cuticle. Our data also suggest that the interaction between DCs and larvae is mediated via C-type lectin receptors (CLRs) as evidenced by an inhibition in DC sequestration on the larvae cuticle after blocking DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin) or MR (mannose receptor).
Additionally, DCs incubated with viable axenic larvae exhibited an immature phenotype as evidenced by the low expression of the maturation markers CD80, CD83, CD86, CD40, andHLA-DR. However, DCs maintained their ability to acquire a mature phenotype in response to LPS. Cytokine expression by DCs stimulated with the larvae was comparable to untreated DC,with a statistical significance in contrast to LPS treated DCs (p≤0.029 IL-6, 8 and 10). DCs co-stimulated with LPS and N. americanus exhibited an overall suppression of anti- and pro-nflammatory cytokines (IL-6, IL-8, IL-10 and IL-12). Conclusively, mature DCs lyse the parasite, which is thought to be mediated through DC modification of cytokine secretions in the microenvironment via paracrine signalling to directly eliminate and lyse the pathogen.These data provide new insights into early immunological events at the interface of DCs and N. americanus larvae and could explain how L3 evade immunity upon initial interaction with ntigen presenting cells; an essential measure for disease prevention, which will be published later this year
Singapore General Hospital
Yong Yang has completed his PhD at 2007 from National University of Singapore. He is the director of Epidemiology Department of a large tertiary care hospital in Singapore. He has strong experience in epidemiological study with the usage of hospital discharge database. He has conducted hospital epidemiological and clinical research on chronic diseases and infection disease using the hospital discharge database for the past 10 years. He is now developing a comprehensive hospital discharge database, which may be used to conduct epidemiological research in various fields. He has published more than 30 papers in reputed journals
Diabetics Mellitus (DM) has been associated with increased risk of developing tuberculosis (TB). However, information about the extent and risk factors for TB among Asian diabetic patients is scarce. The aim of this study was to assess the rate of TB in patients with DM, and investigate the effect of DM on TB using hospital administrative database. This is an historical cohort study of hospital discharge database from 2004 to 2015 to identify cases with DM and TB using International Statistical Classification of Diseases and Related Health Problems, 9/10th Revision, Australian Modification (ICD-9/10-AM) codes. Of 406751 hospitalized patients, 80493 (19.8%) patients had DM and 2358 (0.6%) patients had TB. Patients with DM had a significantly higher rate of TB (0.71% vs. 0.55%, p<0.001) compared to patients without DM. This higher rate was only present in the pulmonary TB group (0.62% vs. 0.44%, p<0.001) but not in the extrapulmonary TB group (0.11% vs. 0.08%, p=0.053). Logistic regression analyses showed that DM was a significant and independent predictor of TB (odds ratio 1.2, 95% CI 1.1-1.3, p<0.001) after adjustment for factors such as age, gender, ethnicity, admission class, nutritional deficiency, HIV infection, and other comorbid conditions. In conclusion, DM patients were found to have higher rates of TB in this group of Asian patient population. Active screening for latent TB should be considered for DM patients
University of Gezira
Sitelbanat studied B. Pharm, M. Pharm (Pharmaceutical Microbiology) at Faculty of Pharmacy, University of Gezira - Sudan and PhD at China Pharmaceutical University School of Life Science and technology 2016, awarded the prize of distinct scientific research (M. Pharm) entitled (Antimicrobial Activity of fifteen medicinal plants in Hospital air contaminants) by senate board University of Gezira, Sudan, June 2008 and awarded the best poster prize entitled (Pharmaco-dynamic of peptide HM-3 and its effect on HCT-116 tumor micro-environment) in the 5th World Congress on Cancer Therapy, Innovations and Novel Approaches in Diagnosis and Treatment of different Cancers, September/ 28-30/ 2015, Atlanta, USA and also awarded the Ideal Woman Prize (Medal), Sudanese Worker Women Union, Cycle (2012-2016), General Secretariat, Government of Sudan, Under Patronage of the Sudan Vice President, May 30rd2016. She is the Deputy Dean Faculty of Pharmacy, University of Gezira, Sudan since January/2017
Wound infections contribute significantly to morbidity and mortality in surgically treated patients. Number of factors contributes to wound infection; however microorganisms are the major causes with bacteria being the most prevalent. Determination of local Bacterial sensitivity patterns to antibiotics is an important to provide a guide for an appropriate management. The present study was designed to investigate the susceptibility of etiological pathogens isolated from the Gezira Hospital for renal diseases and surgery, to different types of antimicrobial agents and the risk factors during the period between August and December 2015. The study followed prospective antimicrobial Agents
Case series for all patients admitted to the surgical wards during this period. The demographic data, diagnostic criteria, and laboratory data were collected. Out of the 200 patients recruited in the study (18%) showed evidence of sepsis yield infections. The predominant isolate was Staphylococcus aureus which represent (31%) of the total isolated Bacteria. Cloxacillin exhibited the highest activity (87%) against Staph aureus while Cefotaxime, Co- trimoxazole and Cefalexin showed only (7%). In contrast to previous study reported that Staph aureus was 100% susceptible to Cefotaxime, this conflict may due to the production of β- lactamase or alternation of the target site with the decrease affinity to the drug and also the diabetic patients showed high incidence of wound infection compared with non diabetic. In conclusion, the rate of surgical site infection was relatively high and the predominant pathogen Staph aureus was highly susceptible to Cloxacillin and resistant to Cefixim.
RN ICC Armed Forces Hospital
Ms. Zarina Bee Nazeer has completed her Diploma in Nursing (General, Psychiatric, Community) and Midwifery from Natal College of Nursing, R K Khan Campus Durban South Africa. She has passed the SAMTRAC Course by NOSA. (Safety Management and Training) (Cum Laude) in 2001.She completed the Infection Prevention & Control Course in 2011 at Netcare Nursing Academy in Durban South Africa. She has more than 28yrs experience in the healthcare setting. She is currently the Infection Control Coordinator at AFHSR in Khamis Mushayt KSA. She has been a speaker on Infection Control Topics locally and internationally. She is a presentator at AFHSR IC Mandatory Training Course for all staff. She has coordinated, co-directed and facilitated IC educational activities and has been extensively involved in major infection control activities, projects and programs for the past 15 years, including commissioning of new facilities, developing surveillance programs and evaluating IC programs.
She is an active team player & has been instrumental in the Infection Control Service element for JCIA at AFHSR. The hospital has successfully passed the Joint Commission International Accreditation (JCIA February 2017).
Patient Safety and Quality Patient Care is the ultimate goal of patient care in any healthcare facility. Infection Prevention and Control is the epicenter of Patient Care Delivery, therefore the Infection Control Programme in Healthcare Settings must include the IC Risk Assessment policy which must be proactively done to prevent infections and outbreaks, by assessing the potential risks which may disrupt the IC efforts.
Infection Control Risk Assessment (ICRA)
Infection Prevention and Control (PCI) Risk Assessment describes the Infection risks which is unique to the institution. This Infection Control Risk Assessment (ICRA) will help the institution to assess the Complexity of the Risk identified and the possible actions to reduce the effects of the risk. The risk scoring will help determine the severity of the risk and the prioritization of each risk identified.
Risk assessment is an ongoing process because infection risk changes overtime and at times rapidly. An infection control risk assessment must consider different elements before establishing IPC policies and procedures, goals and objectives.
A written, hospital wide comprehensive risk assessment plan is essential in any healthcare organization because it is a first step in a systematic process to create and implement PCI Plan.
Infection Control Risk Assessment Plan
The Healthcare Accreditation bodies (viz. JCIA – Standard PCI.7) has included the ICRA as a requirement for written risk assessments documenting how the healthcare facility is prioritizing patient and healthcare worker safety.
The PCI Risk Assessment will be done by the Multidisciplinary Team members which may include representation from Infection Control , Environmental Health & Safety( EH&S) , Facilities & Engineering and Continuous Quality Improvement & Patient Safety (CQI&PS) . The Infection Control Committee members will review and approve the facility wide PCI Risk Assessment and the PCI programme Plan for the set year.